{"id":206,"date":"2023-06-26T21:15:39","date_gmt":"2023-06-26T21:15:39","guid":{"rendered":"http:\/\/liquidbx.org\/?page_id=206"},"modified":"2023-06-27T17:18:49","modified_gmt":"2023-06-27T17:18:49","slug":"activity","status":"publish","type":"page","link":"https:\/\/liquidbx.org\/index.php\/activity\/","title":{"rendered":"Activity"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"206\" class=\"elementor elementor-206\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b206828 e-flex e-con-boxed e-con e-parent\" data-id=\"b206828\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;video&quot;,&quot;background_video_link&quot;:&quot;http:\\\/\\\/liquidbx.org\\\/wp-content\\\/uploads\\\/2023\\\/06\\\/Activity.mp4&quot;,&quot;background_play_on_mobile&quot;:&quot;yes&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-background-video-container\">\n\t\t\t\t\t\t\t<video class=\"elementor-background-video-hosted\" autoplay muted playsinline loop><\/video>\n\t\t\t\t\t<\/div>\t\t<div class=\"elementor-element elementor-element-2a471e1 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"2a471e1\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_delay&quot;:400}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Activity<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d04d4e7 e-flex e-con-boxed e-con e-parent\" data-id=\"d04d4e7\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-362fe44 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"362fe44\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Main Activities<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5911715 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"5911715\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><strong>Multi-omics data<\/strong> &#8211; Generate multi-layered data by measuring genomic, epigenomic, proteomic, metabolomic, and immune signals from healthy donors, and patients with pancreatic cancer, Alzheimer disease, and metabolic liver diseases.<\/li><li><strong>Build generic algorithmic technologies for identification of multi-omics biomarkers<\/strong> &#8211; Multiple efforts are being combined to establish an infrastructure for merging data obtained from various modalities and testing methods performed on the same samples. This enables the implementation of algorithms and deep neural networks to conduct multi-omics prediction.<\/li><li><strong>Coordinating the production and flow of information<\/strong> &#8211; The consortium is working on defining a unified architecture for data collection interfaces and facilitating the transfer of information across all partners. They are also coordinating the collection of data (including samples and tests) and determining the responsibilities of each partner.<\/li><li><strong>Building shared data sets<\/strong> &#8211; fusing the results of different omics data that measure different biomarkers and which will be measured by different members working on different modalities and liquid biopsy sensing technologies.<\/li><li><strong>Clinical validation<\/strong> &#8211; running tests on verified clinical samples to validate the biomarkers identification platforms and their implementation into sensing devices.<\/li><li><strong>Analysis and insights<\/strong> &#8211; Generating insights for Identification of novel liquid biopsy-based multi omics biomarkers that will be used as a basis for the development of future products.<\/li><li><strong>Multi-omics sensors<\/strong> &#8211; Development of modular and disease agnostic sensors to detect combinations of markers with high sensitivity and specificity.<\/li><\/ul><p><strong>\u00a0<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c6d7a3d elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"c6d7a3d\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Work Groups<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f4e7387 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"f4e7387\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>LIQUIDBX Work Groups<\/strong><\/p><p>In order to meet the objectives, the LIQUIDBX participants are organized into four major work groups, which are responsible for:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d2d8f32 e-flex e-con-boxed e-con e-child\" data-id=\"d2d8f32\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-428ef4b e-flex e-con-boxed e-con e-child\" data-id=\"428ef4b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e2eead2 elementor-position-top elementor-invisible elementor-widget elementor-widget-image-box\" data-id=\"e2eead2\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/liquidbx.org\/wp-content\/uploads\/2023\/06\/WG1.jpg\" class=\"attachment-full size-full wp-image-211\" alt=\"\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Work Group 1<\/h3><p class=\"elementor-image-box-description\">Bio-samples & clinical data management<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-361bbef e-flex e-con-boxed e-con e-child\" data-id=\"361bbef\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-38b60c0 elementor-position-top elementor-invisible elementor-widget elementor-widget-image-box\" data-id=\"38b60c0\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/liquidbx.org\/wp-content\/uploads\/2023\/06\/WG2.jpg\" class=\"attachment-full size-full wp-image-213\" alt=\"\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Work Group 2<\/h3><p class=\"elementor-image-box-description\">Multi-Omics sensors technologies development <\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-86171bd e-flex e-con-boxed e-con e-child\" data-id=\"86171bd\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6e43698 elementor-position-top elementor-invisible elementor-widget elementor-widget-image-box\" data-id=\"6e43698\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/liquidbx.org\/wp-content\/uploads\/2023\/06\/WG3.jpg\" class=\"attachment-full size-full wp-image-214\" alt=\"\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Work Group 3<\/h3><p class=\"elementor-image-box-description\">Multi-omics data analysis and algorithm development<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-91bce44 e-flex e-con-boxed e-con e-child\" data-id=\"91bce44\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1ab4c76 elementor-position-top elementor-invisible elementor-widget elementor-widget-image-box\" data-id=\"1ab4c76\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/liquidbx.org\/wp-content\/uploads\/2023\/06\/WG4.jpg\" class=\"attachment-full size-full wp-image-215\" alt=\"\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Work Group 4<\/h3><p class=\"elementor-image-box-description\">Single Omics technology development and data generations<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4af9e0a elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"4af9e0a\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Work Process<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-168b3d0 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"168b3d0\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">The LIQUIDBX operation <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-495eeee elementor-invisible elementor-widget elementor-widget-image\" data-id=\"495eeee\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"http:\/\/liquidbx.org\/wp-content\/uploads\/2023\/06\/work-process.jpg\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"work-process\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MjIwLCJ1cmwiOiJodHRwczpcL1wvbGlxdWlkYngub3JnXC93cC1jb250ZW50XC91cGxvYWRzXC8yMDIzXC8wNlwvd29yay1wcm9jZXNzLmpwZyJ9\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"856\" height=\"863\" src=\"https:\/\/liquidbx.org\/wp-content\/uploads\/2023\/06\/work-process.jpg\" class=\"attachment-full size-full wp-image-220\" alt=\"\" srcset=\"https:\/\/liquidbx.org\/wp-content\/uploads\/2023\/06\/work-process.jpg 856w, https:\/\/liquidbx.org\/wp-content\/uploads\/2023\/06\/work-process-298x300.jpg 298w, https:\/\/liquidbx.org\/wp-content\/uploads\/2023\/06\/work-process-150x150.jpg 150w, https:\/\/liquidbx.org\/wp-content\/uploads\/2023\/06\/work-process-768x774.jpg 768w\" sizes=\"(max-width: 856px) 100vw, 856px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Click on image to enlarge<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-67be6e6 e-flex e-con-boxed e-con e-child\" data-id=\"67be6e6\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2847570 e-flex e-con-boxed e-con e-child\" data-id=\"2847570\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-19b92ad elementor-widget elementor-widget-text-editor\" data-id=\"19b92ad\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>WG1 \u2013 Bio-samples &amp; Clinical data management<\/strong><\/p><ul><li>Collect bio-samples and complimentary clinical data for the three clinical demonstrators<\/li><li>Standardization of the collection conditions (volume, treatment, sample type, preservation conditions).<\/li><li>Managing the use of bio-samples in order to allow maximum coordination between the partners, for optimal usage of bio-samples<\/li><li>Preparing contrived samples for monitoring, and enhancing technology development, and supervising blinded testing.\u00a0<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7678d70 e-flex e-con-boxed e-con e-child\" data-id=\"7678d70\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-88439f2 elementor-widget elementor-widget-text-editor\" data-id=\"88439f2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>WG4 \u2013 Single Omics data generators<\/strong><\/p><ul><li>Develop highly sensitive single omics methods for detecting disease-associated molecules and signals across different platforms to support sensitive and specific detection of extremely low signals at the pre-symptomatic stage. Selection and validation of technologies that produce clinically meaningful data<\/li><li>Standardization of the measurements across all omics &amp; technologies<\/li><li>Provide high quality, reproducible data to the computational group.<\/li><li>Validate biomarkers in blinded testing<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6d65a53 e-flex e-con-boxed e-con e-child\" data-id=\"6d65a53\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f3ab440 e-flex e-con-boxed e-con e-child\" data-id=\"f3ab440\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a114488 elementor-widget elementor-widget-text-editor\" data-id=\"a114488\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>WG3 \u2013 Computational platform, Data Science and Algorithms\u00a0<\/strong><\/p><ul><li>Creating a generic, and available cloud-based solution that accepts complex, and often missing data to produce an optimal collection of biomarkers in a disease agnostic manner.<\/li><li>Normalization of data from different sources<\/li><li>Developing tools for multi omics data integration while dealing with sparse and missing data at the intra and inter sample levels.<\/li><li>Generation of highly interpretive models so that key features are translated into biomarkers<\/li><li>Generate an accessible cloud computational platform for data sharing and identification of biomarkers<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a9ce466 e-flex e-con-boxed e-con e-child\" data-id=\"a9ce466\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-430e9c7 elementor-widget elementor-widget-text-editor\" data-id=\"430e9c7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>WG2 \u2013 Multi-omics sensing technologies for point of care usage<\/strong><\/p><ul><li>From lab to POC: Develop flexible and modular sensors to transform complex and costly single-omics technologies into simple point of care sensing devices<\/li><li>Multi omics on a chip: easily integrated and combinatorial \u201cmix &amp; match\u201d microfluidic based sensors<\/li><li>Combine single-omics sensing technologies into a unified multi-omics measuring device<\/li><li>Machine learning analysis of data from the multi omics sensing device<\/li><li>Validate single and multi omics sensing on clinically relevant samples<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-be5e19c elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"be5e19c\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Core Multi Omics modalities: <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eb026f2 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"eb026f2\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The LIQUIDBX consortium is developing an infrastructure for the development of generic technologies for the identification and detection of biological markers and their integration into modular multi omics, and point of care compatible sensors for the early detection of diseases. The consortium will generate data\u00a0 at the genomic, transcriptomic, epigenomic, metabolic, proteomic, and immune systems levels,the computational tools for its integration and interpretation, and the sensing technologies for implementing multi omics markers in accessible point of care devices.\u00a0 In our work in the consortium, we will focus our research on the following core multi-omics modalities:<\/p><ol><li><strong>Proteomics <\/strong>-plasma mass spectrometry<\/li><li><strong>cfDNA <\/strong>\u2013 targeted and whole genome cell free DNA sequencing<\/li><li><strong>cfRNA <\/strong>\u2013 cell free RNA sequencing<\/li><li><strong>cfDNA Methylation<\/strong> analysis<\/li><li><strong>cfChromatin <\/strong>\u2013 cell free Chromatin immunoprecipitation and sequencing<\/li><li><strong>Blood cells<\/strong> analysis<\/li><li><strong>Mitochondrial <\/strong>function analysis<\/li><li><strong>Immune cells<\/strong> transcriptomics<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2b76142 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"2b76142\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Demonstrators:<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f3e2881 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"f3e2881\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The LIQUIDBX technology platform is being developed, verified, and tested through three distinct demonstrators by our consortium members. These demonstrators were selected based on specific criteria, including their potential for clinical significance and impact on human health, a large untapped market, interest from industrial companies, and our access to relevant biological samples for research and verification.<\/p><p>The three demonstrators are:<\/p><ol><li><strong>Pancreatic cancer<\/strong> (95% fatality rate with no available solutions for early detection)<\/li><li><strong>NAFLD\u00a0\u00a0 &amp; NASH<\/strong>\u00a0 (fatty liver affects nearly 30% of the population. No current solution for early detection)<\/li><li><strong>Alzheimer&#8217;s<\/strong><strong> disease<\/strong> (affects a high percentage of the population. No current solution for early detection)<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3c90c00 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"3c90c00\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Expected Deliverables <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a45d81 e-flex e-con-boxed e-con e-parent\" data-id=\"0a45d81\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-343b895 e-flex e-con-boxed elementor-invisible e-con e-child\" data-id=\"343b895\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-38c1228 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"38c1228\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"128\" height=\"128\" src=\"https:\/\/liquidbx.org\/wp-content\/uploads\/2023\/06\/time-management.png\" class=\"attachment-full size-full wp-image-292\" alt=\"\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Period 1<\/h3><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6b83f18 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"6b83f18\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>A transparent system for managing biological samples<\/li><li>Protocols for collection and preservation for optimal use of bodily fluids by many technologies.<\/li><li>Unified biological standards for training and evaluation<\/li><li>Improvement of single omics technologies for maximal sensitivity and specificity as required for early detection<\/li><li>Cloud infrastructure for receiving and processing the various omics data<\/li><li>An array of cloud based algorithms for multi-omics data processing<\/li><li>Sensors with sufficient sensitivity and modularity to allow flexible development of products that allow multi omics-based early detection at the point of care. <\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-edc85bd e-flex e-con-boxed elementor-invisible e-con e-child\" data-id=\"edc85bd\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6ede4d1 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"6ede4d1\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"128\" height=\"128\" src=\"https:\/\/liquidbx.org\/wp-content\/uploads\/2023\/06\/time-management.png\" class=\"attachment-full size-full wp-image-292\" alt=\"\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Period 2<\/h3><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8c10834 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"8c10834\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Generation of Multi-omics data &#8211; Generate data from all omics on at least 100 samples for each of the tested diseases and a complementary healthy cohort<\/li><li>Integrated data &#8211; for the purpose of identifying the complex biomarkers<\/li><li>Multi-omics POC sensing platform ready<\/li><li>Modular sensors capable of measuring multi-omics at the point of care<\/li><li>Identification of complex biomarkers for the target diseases that are compatible with point of care sensing.<\/li><li>Validation of the biomarkers and the sensors for detecting the relevant diseases<\/li><li>Improved algorithms for working on multi-omics to find complex biomarkers<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Activity Main Activities Multi-omics data &#8211; Generate multi-layered data by measuring genomic, epigenomic, proteomic, metabolomic, and immune signals from healthy donors, and patients with pancreatic cancer, Alzheimer disease, and metabolic liver diseases. Build generic algorithmic technologies for identification of multi-omics biomarkers &#8211; Multiple efforts are being combined to establish an infrastructure for merging data obtained [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-206","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/liquidbx.org\/index.php\/wp-json\/wp\/v2\/pages\/206","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/liquidbx.org\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/liquidbx.org\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/liquidbx.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/liquidbx.org\/index.php\/wp-json\/wp\/v2\/comments?post=206"}],"version-history":[{"count":28,"href":"https:\/\/liquidbx.org\/index.php\/wp-json\/wp\/v2\/pages\/206\/revisions"}],"predecessor-version":[{"id":410,"href":"https:\/\/liquidbx.org\/index.php\/wp-json\/wp\/v2\/pages\/206\/revisions\/410"}],"wp:attachment":[{"href":"https:\/\/liquidbx.org\/index.php\/wp-json\/wp\/v2\/media?parent=206"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}