Taking Multi-Omics Liquid Biopsy
to Point of Care Diagnosis

A Generic Toolbox for Multi-Omics Sensing

About LiquidBX

Aims & Objectives

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A Generic infrastructure for developing tools for early, accurate and accessible diagnosis of human diseases

In today’s global healthcare landscape, there’s a pressing demand for technologies that allow for a much earlier diagnosis, when diseases can be cured, which, in turn also reduces treatment costs while relieving pressure on health systems.

However, the main obstacle to achieving this goal is developing technologies that are sensitive, precise, and readily available.

Innovation

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Current State of the Art in liquid Biopsy

The current state of liquid biopsy technology is primarily focused on sensitive cancer detection for early diagnosis and residual disease monitoring. The major players in the field are primarily concentrating their efforts on a single measurement, mainly genomics or DNA methylation-based technologies.

Diagnosis is largely based on markers derived from the tumor itself, and most efforts are geared towards complex and relatively costly technologies that require laboratory services.

Expected Outcome

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A Multi-Omics platform for early pre-symptomatic detection of disease markers

LIQUIDBX consortium is developing an infrastructure for the development of a generic  technological toolbox for the detection of biological markers and their integration into modular generic sensors for the early detection of diseases. The multi-omic sensors will identify signals coming from multiple biological elements including genomics, epigenomics, metabolomics, proteomics, the immune system and more.

Multi-Omics platform for early pre-symptomatic
detection of disease markers

click on image to enlarge

Main Activities

  • Multi-omics data – Generate multi-layered data by measuring genomic, epigenomic, proteomic, metabolomic, and immune signals from healthy donors, and patients with pancreatic cancer, Alzheimer disease, and metabolic liver diseases.

  • Build generic algorithmic technologies for identification of multi-omics biomarkers – Multiple efforts are being combined to establish an infrastructure for merging data obtained from various modalities and testing methods performed on the same samples. This enables the implementation of algorithms and deep neural networks to conduct multi-omics prediction.

  • Coordinating the production and flow of information – The consortium is working on defining a unified architecture for data collection interfaces and facilitating the transfer of information across all partners. They are also coordinating the collection of data (including samples and tests) and determining the responsibilities of each partner.

  • Building shared data sets – fusing the results of different omics data that measure different biomarkers and which will be measured by different members working on different modalities and liquid biopsy sensing technologies.

  • Clinical validation – running tests on verified clinical samples to validate the biomarkers identification platforms and their implementation into sensing devices.

  • Analysis and insights – Generating insights for Identification of novel liquid biopsy-based multi omics biomarkers that will be used as a basis for the development of future products.

  • Multi-omics sensors – Development of modular and disease agnostic sensors to detect combinations of markers with high sensitivity and specificity.

Consortium Members

Partners

Israel’s Innovation Authority backed Genome Editing Consortium

The LIQUIDBX consortium is supported with research and development grants from the Innovation Authority of Israel (IAI). The LIQUIDBX consortium operates under the Magnet Consortium track of the IAI.

The support of the Innovation Authority of Israel through the LIQUIDBX consortium enables the member companies to be at the forefront of the liquid biopsy field worldwide while recruiting leading scientists and deploying innovative technologies developed in Israel. 

News & Events

May 2023

Solid-state nanopores (ssNPs) are single-molecule sensors capable of label-free quantification of different biomolecules…

Jan 2023

LIQUIDBX members, Professors Yuval Dor, Tommy Kaplan and Ben Glaser announce breakthrough in liquid biopsy research. 

Contact Us

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