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The Yossifon’s lab is focused on developiing micro/nano-fluidics technology with special focus on electrokinetic phenomena (i.e. manipulation of fluid and bioparticles using electric fields) for biosensning, separation, sample preprocessing.
The need for multi-Ohmic sensing is due to the fact that there is no single biomarker that is indicative of a disease as well as no single sensing approach that is valid for all type of biomarkers and test conditions. A solution to this is the fusion of several different sensing and sample processing technologies. The microfluidic technology which we develop can support such fusion by integrating sensors within a microfluidic chip to enable its use for liquid biopsy, interfacing between off-chip sample preprocessing and sensors as well as performing on-chip sample preprocessing through sophisticated manipulation, including electrokinetics, of fluids and bioparticles.
Here, we develop a generic microfluidic platform for on-chip sample processing which on the one-hand interfaces off-chip sample preprocessing technologies of Senseera and Salignostics while on the other-hand, its output, interfaces Prof. Amit Meller’s nanopore sensor. In addition, we develop a specialized microfluidic system with/without electrokinetics to enable the use of MSTech’s quartz-crystal microbalance (QCM) for biosensing of biomarkers existing in a fluidic environment of the liquid biopsy.
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