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The Dor Lab at the Faculty of Medicine of the Hebrew university of Jerusalem is studying tissue dynamics: organ development, regeneration and failure, particularly in the context of the pancreas and related diseases such as diabetes and pancreatic cancer. In the last decade we have established a non-invasive assay for detecting tissue-specific cell death in the human body. When cells die in the human body, their broken DNA is released into blood. The DNA of each cell type carries a unique methylation pattern, which survives in circulating DNA fragments released from dying cells. By detecting the unique methylation profiles of circulating DNA molecules, we can determine their source tissue and recognize multiple disease processes.
Our Liquid Biopsy vision is to achieve assay sensitivity and specificity that will allow for actionable detection of pathologies, including early detection of disease such as pancreatic cancer, fatty liver diseases, and Alzheimer’s. A key methodology towards this vision is the establishment of multiple DNA methylation markers for each human cell type.
Our activity in the consortium will include the profiling of DNA methylation patterns in plasma samples from healthy controls and patients with pancreatic cancer, liver disease and Alzheimer’s disease. Our team includes prof. Ruth Shemer, Dr Ofra Sabag, and graduate student Offer Gal.
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